van der Stock J, de Schepper J
Res Vet Sci. 1978 Nov;25(3):337-42.
After oral administration of sublethal doses of thallium (lower than 10 mg/kg) to dogs, 75.5 +/- 3.9 per cent of the dose was eliminated from the body--47 per cent faecal and 28 per cent urinary. Cumulative excretion reached 50 and 70 per cent after 10 and 25 days respectively, and was almost complete after 75 days. This was slightly lower at higher doses. The total body-burden of thallium, calculated from the cumulative excretion, decreased exponentially for at least the first 40 days with a half-time (T 1/2) of 6.5 days. Oral doses of Prussian blue after 10 days resulted in an acceleration of the thallium elimination from the body (T 1/2 2.5 days), an increase of the faecal (49 per cent) and a decrease of the urinary excretion (18 per cent). Nevertheless, the cumulative faecal and urinary thallium excretion was not influenced. Minor transitory influences of Prussian blue on the faecal thallium excretion could be observed up to day 26. After 40 days, Prussian blue could no longer influence the faecal thallium excretion. At no time did sodium-ethylenediaminetetraacetic (Na2EDTA) acid significantly change faecal or urinary thallium excretion.
给狗口服亚致死剂量的铊（低于10毫克/千克）后，75.5±3.9%的剂量从体内排出——47%通过粪便排出，28%通过尿液排出。10天和25天后累积排泄量分别达到50%和70%，75天后几乎完全排出。高剂量时这一比例略低。根据累积排泄量计算，铊在体内的总负荷至少在前40天呈指数下降，半衰期（T1/2）为6.5天。10天后口服普鲁士蓝可加速铊从体内的排出（T1/2为2.5天），粪便排泄量增加（49%），尿液排泄量减少（18%）。然而，粪便和尿液中铊的累积排泄量不受影响。直到第26天，可观察到普鲁士蓝对粪便中铊排泄有轻微的短暂影响。40天后，普鲁士蓝不再影响粪便中铊的排泄。乙二胺四乙酸钠（Na2EDTA）在任何时候都不会显著改变粪便或尿液中铊的排泄。
