Marzo A, Ghirardi P, Alessio R, Villa A
Arzneimittelforschung. 1977;27(12):2343-4.
The pharmacokinetic behavior of (3,5,6-3H)-raubasine (RAU) was investigated in human subjects after oral administration and in dogs after both intravenous and oral administration. By the oral route RAU peak plasma levels appeared in human subjects after 1 h and in dogs after 2 h. Three-day cumulative urinary excretion was 22% by i.v. route and 13% by oral route in dogs, being 29% in human subjects after oral administration. Three-day cumulative faecal excretion in dogs was 51% by i.v. route and 57% by oral route whilst it was 24% in humans. From a comparison between the urinary excretion values observed after i.v. and oral administration, a RAU intestinal absorption of 59% may be obtained.
研究了(3,5,6 - 3H)-萝巴新（RAU）在人体口服给药后以及在犬静脉注射和口服给药后的药代动力学行为。经口服途径，RAU在人体1小时后出现血浆峰值水平，在犬2小时后出现。犬经静脉途径给药后3天累积尿排泄率为22%，经口服途径为13%，人体口服给药后为29%。犬经静脉途径给药后3天累积粪便排泄率为51%，经口服途径为57%，而人体为24%。通过比较静脉注射和口服给药后观察到的尿排泄值，可得RAU的肠道吸收率为59%。
