Kent D, Pennie F, Laws D, White S, Clark D
Eye Department, University Hospital Aintree, Liverpool, UK.
Eye (Lond). 2000 Feb;14 ( Pt 1):23-9. doi: 10.1038/eye.2000.6.
Retinopathy of prematurity (ROP) stage 3 eyes that require treatment have a greater tendency to myopia compared with eyes with mild ROP. As the mechanisms controlling this myopia are as yet ill understood, we undertook this study to investigate what effect the initial stage of ROP and modality of treatment had on ocular growth.
Eighty-five children were assessed. All children were refracted and underwent 'through-the-lid' biometry using the Zeiss Humphrey biometer 820. The printout obtained was then recorded on video so that the scan could be captured on computer for formal calibration and measurement by a masked observer. Differences in the distribution of variables between the stages of ROP were analysed by one-way analysis of variance, non-parametric Kruskal-Wallis one-way analysis of variance or Mann-Whitney U-test as appropriate.
A difference between the stages of ROP was apparent only for posterior segment length (PSL) (R: p = 0.03; L: p = 0.05) and a borderline difference for anterior chamber depth (ACD) (R: p = 0.06; L: p = 0.06). However, if stage 3 was divided into categories of treated and untreated, axial length (AL) achieved borderline significance (R: p = 0.07; L: p = 0.05) but with no difference between laser-treated and the other stages for AL. Lens thickness (LT) also appears to be influenced by type of treatment (R: p = 0.06; L: p = 0.13). Myopia was associated with stage 3 (R + L: p = 0.0001) and if stage 3 was subdivided the significance was maintained only for the laser- and cryotherapy-treated eyes.
Laser-treated eyes were less myopic than those treated with cryotherapy. AL does not explain all the myopia found in stage 3 treated eyes. The study confirms the tendency towards anterior segment arrest in stage 3 ROP.
与轻度早产儿视网膜病变（ROP）的眼睛相比，需要治疗的3期ROP眼睛更易出现近视。由于控制这种近视的机制尚不清楚，我们开展了这项研究，以调查ROP初始阶段和治疗方式对眼球生长有何影响。
评估了85名儿童。所有儿童均进行验光，并使用蔡司汉弗莱生物测量仪820进行“透过眼睑”生物测量。然后将获得的打印结果记录在视频上，以便扫描可以在计算机上捕获，由一位不知情的观察者进行正式校准和测量。根据情况，采用单因素方差分析、非参数Kruskal-Wallis单因素方差分析或Mann-Whitney U检验分析ROP各阶段之间变量分布的差异。
ROP各阶段之间的差异仅在眼后段长度（PSL）方面明显（右眼：p = 0.03；左眼：p = 0.05），在前房深度（ACD）方面有临界差异（右眼：p = 0.06；左眼：p = 0.06）。然而，如果将3期分为治疗组和未治疗组，眼轴长度（AL）达到临界显著性（右眼：p = 0.07；左眼：p = 0.05），但激光治疗组与其他阶段的AL无差异。晶状体厚度（LT）似乎也受治疗类型的影响（右眼：p = 0.06；左眼：p = 0.13）。近视与3期相关（双眼：p = 0.0001），如果将3期细分，仅激光和冷冻治疗的眼睛仍保持显著性。
激光治疗的眼睛比冷冻治疗的眼睛近视程度轻。AL不能解释3期治疗眼睛中发现的所有近视情况。该研究证实了3期ROP存在前段生长停滞的趋势。
