Cauduro Ricardo Salles, Moraes Nilva Simeren Bueno de, Goulart Ana Lucia, Allemann Norma
Department of Ophthalmology and Visual Sciences, Escola Paulista de Medicina, Federal University of São Paulo, São Paulo, Brazil.
Division of Neonatal Pediatrics, Escola Paulista de Medicina, Federal University of São Paulo, São Paulo, Brazil.
Ophthalmol Sci. 2025 May 20;5(6):100829. doi: 10.1016/j.xops.2025.100829. eCollection 2025 Nov-Dec.
The purpose is to document ocular growth using ultrasound biometry measurements in conditions of prematurity with or without retinopathy.
An observational prospective study.
One hundred twenty eyes of preterm infants in the neonatal intensive care unit.
Follow-up every 2 weeks until 6 weeks postnatally. Inclusion criteria <1500 g or 32 gestational weeks/exclusion criteria >1500 g or 32 gestational weeks.
Ocular biometric parameters were evaluated using B-scan ultrasound (7.5-15 MHz, Mylab Esaote). These included anterior chamber depth, anterior-posterior lens diameter (lens thickness), vitreous chamber depth, and axial length. Additional evaluation parameters included refraction using retinoscopy to determine the refractive error, indirect ophthalmoscopy with 28 diopter lenses, and pediatric biometric parameters recorded in the medical record.
Total number: 120 eyes, 60 patients (29 females; 31 males); retinopathy of prematurity (ROP) number: 48 eyes, 24 patients (13 females; 11 males) were included, and the right eye was analyzed. Through repeated analysis of variance, a statistically significant effect on ROP did not differ significantly from any of the measures evaluated by the rest of the group. The biometric parameter showed a positive correlation relationship with gestational age. However, the refractive spherical was observed in the opposite behavior. The lens thickness and spherical equivalent were not shown. There was a significant correlation with gestational age; only the spherical equivalent significantly correlated with the Z-weight score for gestational age.
In this study, it was possible to document the pattern of ocular growth in preterm infants with the progression of gestational age without differentiation between the groups of preterm infants (with and without ROP).
The author(s) have no proprietary or commercial interest in any materials discussed in this article.
旨在通过超声生物测量法记录早产且伴有或不伴有视网膜病变情况下的眼部生长情况。
一项前瞻性观察研究。
新生儿重症监护病房中的120例早产儿的眼睛。
出生后每2周随访一次，直至出生后6周。纳入标准为体重<1500克或孕周<32周/排除标准为体重>1500克或孕周>32周。
使用B超超声（7.5 - 15兆赫兹，迈瑞ESAOTE）评估眼部生物测量参数。这些参数包括前房深度、晶状体前后径（晶状体厚度）、玻璃体腔深度和眼轴长度。其他评估参数包括使用检影验光法确定屈光不正、使用28屈光度镜片进行间接检眼镜检查以及病历中记录的儿科生物测量参数。
总数：120只眼，60例患者（29例女性；31例男性）；早产儿视网膜病变（ROP）数量：纳入48只眼，24例患者（13例女性；11例男性），并对右眼进行分析。通过重复方差分析，对ROP有统计学显著影响的因素与该组其他评估指标相比无显著差异。生物测量参数与孕周呈正相关关系。然而，屈光球镜度数表现出相反的趋势。未显示晶状体厚度和等效球镜度数。与孕周有显著相关性；只有等效球镜度数与孕周的Z评分显著相关。
在本研究中，有可能记录早产儿眼部生长模式随孕周进展的情况，且未区分早产儿组（有和无ROP）。
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