Sabo D, Brocai D R, Eble M, Wannenmacher M, Ewerbeck V
Department of Orthopaedic Surgery, University of Heidelberg, Germany.
J Bone Joint Surg Br. 2000 Mar;82(2):276-82.
We studied the effects of irradiation on the reintegration of autologous osteoarticular grafts over a period of 24 weeks in a canine model. In 16 foxhounds the medial femoral condyle was resected, irradiated and immediately replanted. In the control group resection and replantation were performed without irradiation. Reintegration was assessed by macroscopic analysis, histology, radiography and gait analysis. Reintegration was equal at 12 weeks, but significantly inferior in the irradiated group after 24 weeks with delayed bone remodelling. The articular cartilage showed modest degeneration. Conventional radiography and histology showed corresponding changes. Limb function was adequate but the gait was inferior in the treated group.
我们在犬类模型中研究了照射对自体骨关节移植再整合的影响，观察期为24周。对16只猎狐犬的内侧股骨髁进行切除、照射并立即重新植入。对照组则在不进行照射的情况下进行切除和重新植入。通过宏观分析、组织学、放射学和步态分析来评估再整合情况。12周时再整合情况相同，但24周后照射组的再整合明显较差，伴有骨重塑延迟。关节软骨出现轻度退变。传统放射学和组织学显示出相应变化。治疗组的肢体功能尚可，但步态较差。
