Mihalache C, Mihalache G, Mihalache L I, Indrei A
Disciplina de Medicină Muncii, Facultatea de Medicină, Universitatea de Medicină şi Farmacie Gr. T. Popa, Iaşi.
Rev Med Chir Soc Med Nat Iasi. 1997 Jul-Dec;101(3-4):91-4.
The histopathological and ultrastructural aspects of cerebral cortex were followed up in the white rat injected intraperitoneally with carbon disulphide at 5 mg/kg body weight/week, in a chronic experiment--3, 6, 10 months. Important neuronal damages like: neuronal dystrophy's to neurolysis affecting the pyramidal and granular cells, neuronophagy, nodular and diffuse glial reaction, in the absence of atherosclerotic lesions were noticed. The lesions developed after 3 months and become more extended at 6 months and 10 months: it persists even after 2 months from the moment when the administration ceased.
在一项慢性实验中，对白鼠腹腔注射二硫化碳，剂量为5毫克/千克体重/周，持续3、6、10个月，之后对其大脑皮层的组织病理学和超微结构方面进行了随访。观察到了重要的神经元损伤，如：影响锥体细胞和颗粒细胞的神经元营养不良至神经元溶解、神经元吞噬、结节性和弥漫性胶质反应，且未发现动脉粥样硬化病变。病变在3个月后出现，并在6个月和10个月时更加广泛：即使在停止给药2个月后仍持续存在。
