Cojocaru I, Irimia O, Constantin T
Facultatea de Farmacie, Universitatea de Medicină şi Farmacie Gr. T. Popa, Iaşi.
Rev Med Chir Soc Med Nat Iasi. 1997 Jul-Dec;101(3-4):166-9.
Erythromycin associated with progesterone and A vitamin has been included in three dermatological pharmaceutical forms: a lotion, a L/H emulsion and a L/H nonionogenic ointment. Aspect of these preparations has been noticed for a 90 days period. pH and electrical conductance were also determined during this interval. All the formulations mentioned above revealed insignificant variations of these parameters proving an appreciable physico-chemical stability. Clinical investigative studies in juvenile acne, showed efficiency, particularly for the emulsion form.
红霉素与孕酮及维生素A已被制成三种皮肤科用药剂型：洗剂、水/油乳液和水/油非离子软膏。对这些制剂的外观进行了为期90天的观察。在此期间还测定了pH值和电导率。上述所有制剂的这些参数变化均不显著，证明其具有相当的物理化学稳定性。针对青少年痤疮的临床研究表明这些制剂有效，尤其是乳液剂型。
