Charakida A, Charakida M, Chu A C
Department of Dermatology, Hammersmith Hospital, DuCane Road, London W12 0NN, UK.
Br J Dermatol. 2007 Sep;157(3):569-74. doi: 10.1111/j.1365-2133.2007.08083.x. Epub 2007 Jul 16.
Acne vulgaris is a major clinical problem; despite a vast array of treatment modalities available for acne, there is considerable dissatisfaction in acne treatment among patients and doctors. Rising antibiotic drug resistance consequent to the widespread use of topical antibiotics is causing concern and effective nonantibiotic treatments are needed.
To evaluate the efficacy and tolerability of a novel lotion containing triethyl citrate and ethyl linoleate in the treatment of mild to moderate acne vulgaris.
This was a double-blind, placebo-controlled, randomized study comparing the active lotion containing triethyl citrate and ethyl linoleate with its vehicle as a placebo control. Patients were assessed by the modified Leeds acne grading system as well as by counting inflammatory and noninflammatory lesions on the face at weeks 0, 4, 8 and 12. Sebum production was assessed by the Sebutape method at weeks 0 and 12. All adverse events were recorded.
Forty patients were recruited into the study, of whom 33 completed the study. Active treatment was statistically superior to placebo in reduction of Leeds grading and total, inflammatory and noninflammatory lesion counts. The active lotion showed a rapid response with obvious reduction in lesion counts and acne grading by 4 weeks. Sebum production was significantly reduced in the actively treated group, with a mean reduction of 53% in sebum production compared with baseline. One patient developed irritation to the active lotion and withdrew from the study.
The new lotion containing triethyl citrate and ethyl linoleate has been shown to be an effective treatment for mild to moderate acne, with an effect on both inflammatory and noninflammatory acne lesions. The new lotion worked quickly and was generally well tolerated. A surprising finding was the significant impact the new lotion has on sebum production, suggesting a role in patients with seborrhoea. This nonantibiotic preparation will be a very useful addition to existing treatments for acne.
寻常痤疮是一个主要的临床问题；尽管有大量治疗痤疮的方法，但患者和医生对痤疮治疗仍存在相当大的不满。由于局部抗生素的广泛使用导致抗生素耐药性上升，这引起了人们的关注，因此需要有效的非抗生素治疗方法。
评估一种含有柠檬酸三乙酯和亚油酸乙酯的新型洗剂治疗轻度至中度寻常痤疮的疗效和耐受性。
这是一项双盲、安慰剂对照、随机研究，将含有柠檬酸三乙酯和亚油酸乙酯的活性洗剂与其赋形剂作为安慰剂对照进行比较。在第0、4、8和12周，通过改良的利兹痤疮分级系统以及对面部炎性和非炎性皮损进行计数来评估患者。在第0和12周通过皮脂胶带法评估皮脂分泌。记录所有不良事件。
40名患者被纳入研究，其中33名完成了研究。在降低利兹分级以及减少总皮损数、炎性和非炎性皮损计数方面，活性治疗在统计学上优于安慰剂。活性洗剂显示出快速反应，到4周时皮损计数和痤疮分级明显降低。活性治疗组的皮脂分泌显著减少，与基线相比，皮脂分泌平均减少53%。一名患者对活性洗剂产生刺激并退出研究。
已证明含有柠檬酸三乙酯和亚油酸乙酯的新型洗剂是治疗轻度至中度痤疮的有效方法，对炎性和非炎性痤疮皮损均有效果。新型洗剂起效迅速，且总体耐受性良好。一个令人惊讶的发现是新型洗剂对皮脂分泌有显著影响，这表明其在脂溢性皮炎患者中具有一定作用。这种非抗生素制剂将是现有痤疮治疗方法中非常有用的补充。
