Slătineanu S M, Haulică I, Costuleanu A, Mândreci I, Petrescu G
Disciplina de Fiziologie, Facultatea de Medicină, Universitatea de Medicină şi Farmacie Gr. T. Popa, Iaşi.
Rev Med Chir Soc Med Nat Iasi. 1999 Jul-Dec;103(3-4):140-6.
The effects of the conversion enzyme on the hydroelectrolytic balance in adult rats, maintained in standard lab conditions have been followed. The administration protocol for the conversion inhibitor (captopril) produced a blocking of the transformation of angiotensin I in angiotensin II only at the level of the cerebral structures, during the whole period of the treatment (40 micrograms/kg x 3/24 hours). Following the intracerebroventricular (ICV) administration of captopril, the fluid ingestion decreased diuresis and urinary elimination of Na+ and Ca++ increased. The results plead for the existence of a cerebral renin-angiotensin system, which intervenes in the control of the hydroelectrolyte metabolism.
在标准实验室条件下，对成年大鼠体内转化酶对水电解质平衡的影响进行了跟踪研究。在整个治疗期间（40微克/千克×3次/24小时），转化酶抑制剂（卡托普利）的给药方案仅在脑结构水平上阻断了血管紧张素I向血管紧张素II的转化。脑室内注射卡托普利后，液体摄入量减少，钠和钙的利尿及尿排泄增加。这些结果表明存在一种脑肾素-血管紧张素系统，它参与了水电解质代谢的控制。
