Hosseini Mahmoud, Alaei Hojjat Allah, Headari Rahelah, Eslamizadeh Mohammad Javad
Department of Physiology, Mashhad University of Medical Sciences, Mashhad, Iran.
Indian J Exp Biol. 2009 May;47(5):361-7.
With an aim to investigate the effects of injection of angiotensin II (Ang II) and captopril into the nucleus accumbens (NAC) on morphine self-administration, male Wistar rats were first trained to receive small pellets of food by pressing the active lever in self-administration apparatus. The animals, divided into 4 groups (saline, morphine, captopril and Ang II) were placed in self-administration apparatus and were allowed to self-administer morphine (0.5 mg per infusion all test groups) or saline (saline group) during consecutive days, for 2 h/sessions. Captopril (30 microg) and Ang II (0.25 nM) were injected into NAC in the corresponding groups before each session. In morphine group, the number of active lever pressing was significantly higher than passive during all 5 days and was also significantly higher than saline group. In captopril group, there were no significant differences between the number of active and passive lever pressings. However, the number of active lever pressing was significantly lower than morphine group. The results highlight the interaction between captopril and opioid system in NAC.
为了研究向伏隔核（NAC）注射血管紧张素II（Ang II）和卡托普利对吗啡自我给药的影响，首先训练雄性Wistar大鼠通过按压自我给药装置中的活动杆来获取小颗粒食物。将动物分为4组（生理盐水组、吗啡组、卡托普利组和Ang II组），放入自我给药装置中，连续数天让它们自我给药吗啡（所有测试组每次输注0.5毫克）或生理盐水（生理盐水组），每次给药2小时。在每次给药前，向相应组的伏隔核注射卡托普利（30微克）和Ang II（0.25纳摩尔）。在吗啡组中，在所有5天内，活动杆按压次数显著高于被动杆按压次数，且也显著高于生理盐水组。在卡托普利组中，主动和被动杆按压次数之间没有显著差异。然而，活动杆按压次数显著低于吗啡组。结果突出了卡托普利与伏隔核中阿片类系统之间的相互作用。
