Leguizamon G, Reece E A
Department of Obstetrics and Gynecology, Washington University Medical Center, St. Louis, Missouri, USA.
J Matern Fetal Med. 2000 Jan-Feb;9(1):70-8. doi: 10.1002/(SICI)1520-6661(200001/02)9:1<70::AID-MFM15>3.0.CO;2-#.
Nephropathy is a complication of diabetes mellitus that can affect women in their reproductive years. This article reviews the effects on treatment on the main factors associated with short- and long-term complications in pregnant women with diabetic nephropathy. Tight glycemic control, adequate treatment of elevated blood pressure, and renal function in early pregnancy are the most significant predictors of maternal and perinatal outcomes. Contemporary methods of perinatal care and adequate treatment of blood pressure allow fetal survival rates of 95%. Furthermore, pregnancy per se does not appear to worsen the natural progression to end-stage renal disease for most women with renal insufficiency. However, patients with moderate to severe renal impairment may experience acceleration of renal disease.
肾病是糖尿病的一种并发症，可影响处于生育年龄的女性。本文综述了糖尿病肾病孕妇短期和长期并发症相关主要因素的治疗效果。严格的血糖控制、充分治疗血压升高以及孕早期的肾功能是母婴结局的最重要预测因素。当代围产期护理方法和充分的血压治疗可使胎儿存活率达到95%。此外，对于大多数肾功能不全的女性而言，妊娠本身似乎并不会使终末期肾病的自然进展恶化。然而，中重度肾功能损害的患者可能会出现肾病加速进展的情况。
