Eltom A, Elnagar B, Elbagir M, Gebre-Medhin M
Department of Women's and Children's Health, University Hospital, Uppsala, Sweden.
Scand J Clin Lab Invest. 2000 Feb;60(1):1-7. doi: 10.1080/00365510050184985.
Serum thyroglobulin and thyrotropin as well as urinary iodine concentrations were measured in healthy, pregnant Swedish (n=27) and Sudanese (n=21) women and the results compared with those of healthy Swedish (n=14) and Sudanese (n=20) non-pregnant controls. The median thyroglobulin concentrations (and interquartile range) in the Swedish pregnant women for the three trimesters were 15.5 (8-24), 10.5 (7-19) and 18.0 (13-25) microg/L, respectively. The median third trimester concentration was higher than both the first and second trimester concentrations, respectively (p<0.0001, p<0.0001). Compared to the control group, the Swedish pregnant women had a significantly higher median thyroglobulin concentration in the third trimester (p<0.05). Among the Sudanese pregnant women, the median serum thyroglobulin concentrations (and interquartile range) were 27.5 (12-40), 25.0 (15-43) and 30.0 (15-67) microg/L during the first, second and third trimesters, respectively. There were no significant differences between these concentrations. Compared to the control group, the Sudanese pregnant women had a significantly higher median thyroglobulin in the third trimester (p<0.01). The Sudanese pregnant women also showed significantly higher median thyroglobulin concentrations than the Swedish pregnant women in all the three trimesters of pregnancy (p<0.05, p<0.001 and p<0.01, respectively). However, there were no significant differences between the two non-pregnant controls. Among the Swedish pregnant women, 40%, 23% and 30% of the subjects showed serum thyroglobulin concentrations above 20 microg/ L during the first, second and third trimesters of pregnancy, respectively. Corresponding figures for the Sudanese pregnant women were 55%, 61% and 64%, respectively. A significantly negative correlation was shown between serum thyroglobulin and urinary iodine concentrations during the second and third trimesters in the Swedish women (r= -0.8, p=0.01 and r= -0.5, p=0.03, respectively), and in the third trimester in the Sudanese women (r= -0.6, p=0.03). No such correlation was observed between thyrotropin and urinary iodine concentration in either the Swedish or the Sudanese pregnant women. It is concluded that serum thyroglobulin is a more sensitive indicator of iodine deficiency than serum thyrotropin during pregnancy.
对瑞典（n = 27）和苏丹（n = 21）健康孕妇以及瑞典（n = 14）和苏丹（n = 20）健康非孕妇对照者测定血清甲状腺球蛋白、促甲状腺激素以及尿碘浓度，并比较结果。瑞典孕妇三个孕期的甲状腺球蛋白浓度中位数（及四分位间距）分别为15.5（8 - 24）、10.5（7 - 19）和18.0（13 - 25）μg/L。孕晚期浓度中位数分别高于孕早期和孕中期（p < 0.0001，p < 0.0001）。与对照组相比，瑞典孕妇孕晚期甲状腺球蛋白浓度中位数显著更高（p < 0.05）。苏丹孕妇中，孕早期、孕中期和孕晚期血清甲状腺球蛋白浓度中位数（及四分位间距）分别为27.5（12 - 40）、25.0（15 - 43）和30.0（15 - 67）μg/L。这些浓度之间无显著差异。与对照组相比，苏丹孕妇孕晚期甲状腺球蛋白中位数显著更高（p < 0.01）。苏丹孕妇在孕期所有三个阶段的甲状腺球蛋白浓度中位数也均显著高于瑞典孕妇（分别为p < 0.05、p < 0.001和p < 0.01）。然而，两个非孕妇对照组之间无显著差异。瑞典孕妇中，孕早期、孕中期和孕晚期分别有40%、23%和30%的受试者血清甲状腺球蛋白浓度高于20μg/L。苏丹孕妇的相应数字分别为55%、61%和64%。瑞典女性孕中期和孕晚期血清甲状腺球蛋白与尿碘浓度之间呈显著负相关（分别为r = -0.8，p = 0.01和r = -0.5，p = 0.03），苏丹女性孕晚期也是如此（r = -0.6，p = 0.03）。瑞典或苏丹孕妇的促甲状腺激素与尿碘浓度之间均未观察到此类相关性。结论是，孕期血清甲状腺球蛋白是比血清促甲状腺激素更敏感的碘缺乏指标。
