El-Mallakh R S, Schurr A, Payne R S, Li R
Mood Disorders Research Program, Department of Psychiatry and Behavioral Sciences, University of Louisville School of Medicine, Louisville, KY 40292-0001, USA.
J Psychiatr Res. 2000 Mar-Apr;34(2):115-20. doi: 10.1016/s0022-3956(99)00045-x.
Alterations in sodium- and potassium-activated adenosine triphosphatase (Na,K-ATPase) activity have been associated with changes of mood states and lithium treatment in bipolar illness. We examined the effects of ouabain and lithium on evoked population responses in rat hippocampal slices. In vitro 3.3 microM ouabain induced cycling between epliptiform activity and unresponsiveness in 18.5% of slices. In vitro ouabain, at 1-10 microM, induced epileptiform multiple spike responses. In vivo lithium pretreatment for 10-21 days produced a significant delay in the onset of this ouabain-induced epileptiform activity compared to control animals. These findings are consistent with other work which suggests that Na, K-ATPase inhibition can both activate and suppress excitable tissues and that lithium pretreatment can mitigate these effects. The implications of these results and others regarding the pathophysiology of bipolar illness are discussed.
钠钾激活三磷酸腺苷酶（Na，K - ATP酶）活性的改变与双相情感障碍患者的情绪状态变化及锂治疗有关。我们研究了哇巴因和锂对大鼠海马切片诱发群体反应的影响。在体外，3.3微摩尔的哇巴因可使18.5%的切片在癫痫样活动和无反应之间循环。在体外，1 - 10微摩尔的哇巴因可诱发癫痫样多棘波反应。与对照动物相比，体内锂预处理10 - 21天可显著延迟哇巴因诱发的癫痫样活动的发作。这些发现与其他研究一致，即Na，K - ATP酶抑制既能激活也能抑制可兴奋组织，且锂预处理可减轻这些影响。本文讨论了这些结果及其他有关双相情感障碍病理生理学的研究结果的意义。
