Mino Y, Oshima I, Tsuda T, Okagami K
Department of Hygiene and Preventive Medicine, Okayama University Medical School, 2-5-1 Shikatacho, Okayama, Japan.
J Psychiatr Res. 2000 Mar-Apr;34(2):133-8. doi: 10.1016/s0022-3956(00)00003-0.
The finding that influenza epidemics are associated with an increased risk of adult schizophrenia has been controversial. Data was obtained from Japan's governmental statistics, the Patient Survey. Index years were defined as 1957/1958, 1962, and 1965, and comparison years were defined 2 years before and 2 years after the index year. Subjects were patients with schizophrenia who were born in the index years of influenza epidemics. Periods 5 months after the influenza epidemics were defined as exposed months. Proportions of patients born during the exposed period in the index years were compared with those of patients born in the corresponding months in the comparison years. The proportions of patients born in the exposed months in the index years were not significantly different from those born in the corresponding months in the comparison years, with odds ratios around 1 in the whole country, the Kanto area, and the Shikoku/Kyushu area where a remarkable influenza epidemic was observed in 1957. No difference was observed in analyses stratified by sex. In Japan, there was no relationship between influenza epidemics and schizophrenic birth.
流感流行与成人精神分裂症风险增加相关这一发现一直存在争议。数据取自日本政府统计资料《患者调查》。索引年份定义为1957/1958年、1962年和1965年，对照年份定义为索引年份前两年和后两年。研究对象为在流感流行索引年份出生的精神分裂症患者。流感流行后5个月的时间段定义为暴露月份。将索引年份暴露期出生的患者比例与对照年份相应月份出生的患者比例进行比较。在全国、关东地区以及1957年观察到显著流感流行的四国/九州地区，索引年份暴露月份出生的患者比例与对照年份相应月份出生的患者比例无显著差异，优势比约为1。按性别分层分析未观察到差异。在日本，流感流行与精神分裂症出生之间没有关联。
