Kunugi H, Nanko S, Takei N, Saito K, Hayashi N, Kazamatsuri H
Department of Psychiatry, Teikyo University School of Medicine, Tokyo.
Am J Psychiatry. 1995 Mar;152(3):450-2. doi: 10.1176/ajp.152.3.450.
Studies in Finland, England, and Denmark have reported that individuals exposed to the 1957 A2 influenza pandemic during their second trimester in utero are at greater risk for later schizophrenia. However, other studies in England, the United States, and Holland reported no such association. The authors' goal was to shed light on these conflicts.
They compared the number of individuals who later developed schizophrenia who were born in the 5 months after the peak prevalence of three distinct 1957 influenza epidemics in Japan with the mean number of individuals who later developed schizophrenia who were born in the corresponding months of the 4 years surrounding the epidemics.
A significantly greater number of females but not males who later developed schizophrenia were born during the risk exposure months than in the non-risk-exposure months.
These findings, although weak, lend support to the claim that in utero exposure to influenza epidemics is a risk factor for adult schizophrenia.
芬兰、英国和丹麦的研究报告称，在子宫内孕中期接触1957年A2型流感大流行的个体，日后患精神分裂症的风险更高。然而，英国、美国和荷兰的其他研究则未发现此类关联。作者的目标是阐明这些矛盾之处。
他们将在日本三次不同的1957年流感流行高峰后5个月内出生且日后患精神分裂症的个体数量，与在这些流行发生年份前后4年的相应月份出生且日后患精神分裂症的个体平均数量进行了比较。
日后患精神分裂症的女性在风险暴露月份出生的人数显著多于非风险暴露月份，而男性则不然。
这些发现虽然不太有力，但支持了子宫内接触流感流行是成人精神分裂症风险因素这一说法。
