Tibbo P, Kroetsch M, Chue P, Warneke L
Department of Psychiatry, University of Alberta Hospital, 1E7.36 WMC, Edmonton, Canada.
J Psychiatr Res. 2000 Mar-Apr;34(2):139-46. doi: 10.1016/s0022-3956(99)00048-5.
To examine the differences in demographic and clinical features of patients with schizophrenia, with or without comorbid obsessive-compulsive disorder (OCD).
Fifty-two subjects were recruited from clinical services in the city of Edmonton, Alberta and assessed for schizophrenia and OCD with structured clinical interviews and standardized clinical rating scales.
The prevalence of OCD in individuals meeting criteria for schizophrenia was 25%. Those subjects having both schizophrenia and OCD scored significantly higher on the Y-BOCS, Hollingshead scale, and GAF; plus significantly lower PANSS negative symptoms and a trend in increased Parkinsonian symptoms compared with individuals with schizophrenia alone.
Our preliminary findings indicate that patients with schizophrenia and OCD vary in selected demographic and clinical measures when compared to patients with schizophrenia alone. Patients with schizophrenia and OCD appear to have less negative symptoms, which may thus be reflected in the decreased GAF scores. It is speculated that patients with schizophrenia and OCD may have a greater propensity to basal ganglia dysfunction than those with schizophrenia alone resulting in increased Parkinsonian symptoms.
研究伴或不伴有共病强迫症（OCD）的精神分裂症患者在人口统计学和临床特征上的差异。
从加拿大阿尔伯塔省埃德蒙顿市的临床服务机构招募了52名受试者，通过结构化临床访谈和标准化临床评定量表对其进行精神分裂症和强迫症评估。
符合精神分裂症标准的个体中强迫症的患病率为25%。与单纯患有精神分裂症的个体相比，同时患有精神分裂症和强迫症的受试者在耶鲁布朗强迫症量表（Y-BOCS）、霍林斯黑德量表和大体功能评定量表（GAF）上得分显著更高；阳性和阴性症状量表（PANSS）阴性症状得分显著更低，帕金森症状有增加趋势。
我们的初步研究结果表明，与单纯患有精神分裂症的患者相比，同时患有精神分裂症和强迫症的患者在特定的人口统计学和临床指标上存在差异。同时患有精神分裂症和强迫症的患者似乎阴性症状更少，这可能反映在GAF得分降低上。据推测，与单纯患有精神分裂症的患者相比，同时患有精神分裂症和强迫症的患者可能更易出现基底神经节功能障碍，从而导致帕金森症状增加。
