Peduto V A, Mezzetti D, Properzi M, Giorgini C
Institute of Anaesthesiology and Intensive Care, University of Perugia School of Medicine, Perugia, Italy.
Eur J Anaesthesiol. 2000 Feb;17(2):138-43. doi: 10.1046/j.1365-2346.2000.00626.x.
To compare ease of maintenance and recovery characteristics of sevoflurane and propofol plus fentanyl in day-care anaesthesia, 60 outpatients undergoing elective surgery of up to 3 h duration were randomized to receive sevoflurane or propofol as their primary anaesthetic. Induction was always carried out with propofol, but a fentanyl bolus 5 microg kg-1 was added in the propofol group. Anaesthesia was supplemented with up to 70% N2O. Significantly shorter times to extubation (10.03 min +/- 3.2 SD vs. 17.2 +/- 7.3; P < 0.001) and emergence (10.4 +/- 3.1 vs. 16.8 +/- 6.4; P < 0.001) were observed in the sevoflurane group. Patients treated with sevoflurane felt less confused, showed better performances in the digit symbol substitution test and achieved higher modified Aldrete scores sooner in the post-operative course. Maintenance of anaesthesia with sevoflurane produces faster emergence and recovery than propofol plus fentanyl after anaesthesia of short to intermediate duration.
为比较七氟醚与丙泊酚加芬太尼用于日间麻醉时的维护便利性及恢复特性，将60例接受时长可达3小时择期手术的门诊患者随机分组，分别接受七氟醚或丙泊酚作为主要麻醉剂。诱导均采用丙泊酚，但丙泊酚组加用了5微克/千克的芬太尼推注。麻醉用高达70%的氧化亚氮补充。七氟醚组的拔管时间（10.03分钟±3.2标准差 vs. 17.2±7.3；P<0.001）和苏醒时间（10.4±3.1 vs. 16.8±6.4；P<0.001）明显更短。接受七氟醚治疗的患者感觉困惑更少，在数字符号替换测试中表现更好，且术后更快获得更高的改良Aldrete评分。在短至中等时长的麻醉后，七氟醚维持麻醉比丙泊酚加芬太尼能产生更快的苏醒和恢复。
