Mayo K H
Department of Biochemistry, Molecular Biology and Biophysics, and the Biomedical Engineering Center, University of Minnesota, Minneapolis, MN 55455, USA.
Trends Biotechnol. 2000 May;18(5):212-7. doi: 10.1016/s0167-7799(00)01439-6.
Advances in the methods used for the chemical synthesis of peptides, and in the accumulation and analysis of numerous X-ray crystallographic and nuclear magnetic resonance protein and peptide structures, have enabled the design and construction of peptides for investigating basic folding principles, making novel structural motifs, modifying functional activities, developing pharmaceutical drugs and creating new biomaterials. The focus of this review is on recent trends in the design and construction of synthetic peptides for basic science and for various biotechnological applications.
用于肽化学合成的方法取得了进展，同时在众多X射线晶体学以及蛋白质和肽的核磁共振结构的积累与分析方面也取得了进展，这使得人们能够设计和构建肽，用于研究基本折叠原理、制造新型结构基序、修饰功能活性、开发药物以及创造新的生物材料。本综述的重点是合成肽设计与构建方面的最新趋势，这些趋势涉及基础科学和各种生物技术应用。
