Research School of Chemistry, Australian National University, Canberra, ACT 2601, Australia.
Curr Opin Chem Biol. 2018 Oct;46:25-32. doi: 10.1016/j.cbpa.2018.03.019. Epub 2018 Apr 12.
Transition-metal catalysis has unlocked new paradigms for the late-stage modification and cyclization of peptides by harnessing the innate reactivity of proteinogenic amino acids. The field is rapidly evolving, with recent advances encompassing three fundamental areas-heteroatom couplings, decarboxylative cross-couplings, and C-H functionalizations-which have markedly extended the scope of conventional peptide modification and bioconjugation strategies. The advances outlined herein facilitate access to high-value peptide targets with promising applications in materials science and drug discovery.
过渡金属催化通过利用天然存在的蛋白质氨基酸的反应活性，为肽的后期修饰和环化开辟了新的范例。该领域发展迅速，最近的进展涵盖了三个基本领域——杂原子偶联、脱羧交叉偶联和 C-H 官能化——这显著扩展了传统肽修饰和生物偶联策略的范围。本文概述的进展为获得具有应用前景的高价值肽靶标提供了便利，这些靶标在材料科学和药物发现中有广泛的应用。
