Criblez D H
Gastroenterologische Abteilung, Medizinische Klinik, Kantonsspital Luzern.
Praxis (Bern 1994). 2000 Mar 9;89(11):450-3.
This article briefly reviews the results of antiviral treatment of chronic hepatitis C with interferon-alpha. Its relation to the natural course of the illness is discussed. Interferon monotherapy achieves definitive viral elimination in a small minority of patients only. The therapeutic response rate can be enhanced by combining interferon-alpha with ribavirin as well as by increasing interferon dosage or prolonging treatment. A number of questions remain unanswered with regard to the optimal treatment modality and cost-effectiveness. Thus the current recommendation is to treat suitable patients within the frame of controlled studies.
本文简要回顾了用α干扰素治疗慢性丙型肝炎的抗病毒治疗结果。讨论了其与疾病自然病程的关系。干扰素单一疗法仅在少数患者中实现了病毒的彻底清除。将α干扰素与利巴韦林联合使用、增加干扰素剂量或延长治疗时间可提高治疗反应率。关于最佳治疗方式和成本效益仍有许多问题未得到解答。因此，目前的建议是在对照研究框架内治疗合适的患者。
