Larionova N A
A. A. Bogomolets National Medical University, Ministry of Public Health of Ukraine, Kiev.
Fiziol Zh (1994). 2000;46(1):63-9.
Executed was modelling of Mönckeberg's arteriosclerosis by injection into rabbits monoiodacetat, ergocalciferol; cholesterol atherosclerosis and combined type of lesion by simultaneous intake of cholesterol and monoiodacetat. Examined was the content of lipoproteins of different classes in blood serum, in aorta tissue--cholesterol, triglycerides, phospholipids. During all implemented ways of actions the change in comparative content of lipoproteins was indicated, what can be estimated as atherogenic. Monoiodacetat model of arteriosclerosis is accompanied with denominated accumulation of lipids in aorta walls, ergocalciferol model with accumulation of triglycerides only.
通过向兔子注射一碘乙酸盐、麦角钙化醇来模拟门克贝格动脉硬化;通过同时摄入胆固醇和一碘乙酸盐来模拟胆固醇动脉粥样硬化及混合型病变。检测了血清、主动脉组织中不同类别脂蛋白的含量——胆固醇、甘油三酯、磷脂。在所有实施的作用方式中,均显示出脂蛋白相对含量的变化,这可被视为致动脉粥样硬化的。动脉硬化的一碘乙酸盐模型伴有主动脉壁脂质的上述积聚,麦角钙化醇模型仅伴有甘油三酯的积聚。