[实验性动脉粥样硬化家兔血液及主动脉中脂质过氧化物含量的增加]
[Increase in the lipid peroxide content in the blood and aortas of rabbits with experimental atherosclerosis].
作者信息
Lankin V Z, Kotelevtseva N V, Tikhaze A K, Titov V N, Gerasimova E N
出版信息
Vopr Med Khim. 1976 Jul-Aug;22(4):513-7.
PMID:1027237
Abstract
Content of lipid peroxides was estimated in blood and aorta of intact rabbits by means of highly sensitive polarographic method, using a mercuric electrode. Content of lipoperoxides in blood and aorta was increased 4.4- and 3.6-fold, respectively, in animals with pronounced experimental atherosclerosis. The oxidation of lipoperoxides caused a distinct increase in content of intermolecular bindings in amino-containing phospholipids in aorta of rabbits with pronounced atheromatosis.
摘要
采用高灵敏度极谱法，使用汞电极，对完整家兔的血液和主动脉中的脂质过氧化物含量进行了测定。在患有明显实验性动脉粥样硬化的动物中，血液和主动脉中脂质过氧化物的含量分别增加了4.4倍和3.6倍。脂质过氧化物的氧化导致患有明显动脉粥样硬化的家兔主动脉中含氨基磷脂的分子间结合物含量显著增加。
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