Wrońska-Nofer T, Laurman W, Szendzikowski S, Kołakowski J, Wegrowski J
Med Pr. 1980;31(4):311-8.
In the studies carried out lipids content in blood serum and aorta wall as well as morphological changes in coronary vessels of CS2 exposed rats have been evaluated. The 10-month-exposure to CS2 at a concentration of 0,8--0,9 mg/l has been found to result in: (1) increased concentration of total and free cholesterol, cholesterol esters, triglycerides and phospholipids in blood serum; (2) increase in total cholesterol and significant rise in the level of cholesterol esters in the aorta wall; (3) a relative increase in serum VLDL, LDL and decrease in HDL fraction. Histological estimation has demonstrated in serial sections of hearts of the CS2 exposed animals thickened walls of left coronary artery branches with no lipid deposits. In two animals focal steatosis of aortic bulb wall and aortic valves and lipids droplets in endothelium of ascending aorta and coronary vessels have been found.
在已开展的研究中，对暴露于二硫化碳的大鼠的血清和主动脉壁中的脂质含量以及冠状血管的形态变化进行了评估。结果发现，大鼠在浓度为0.8 - 0.9毫克/升的二硫化碳环境中暴露10个月会导致：（1）血清中总胆固醇、游离胆固醇、胆固醇酯、甘油三酯和磷脂的浓度增加；（2）主动脉壁中总胆固醇增加，胆固醇酯水平显著上升；（3）血清极低密度脂蛋白（VLDL）、低密度脂蛋白（LDL）相对增加，高密度脂蛋白（HDL）组分减少。组织学评估显示，在暴露于二硫化碳的动物心脏连续切片中，左冠状动脉分支壁增厚，无脂质沉积。在两只动物中，发现主动脉球壁和主动脉瓣有局灶性脂肪变性，升主动脉和冠状血管内皮中有脂质小滴。
