Frikke-Schmidt R, Tybjaerg-Hansen A, Steffensen R, Jensen G, Nordestgaard B G
Department of Clinical Biochemistry, Herlev University Hospital, Denmark.
J Am Coll Cardiol. 2000 Apr;35(5):1192-9. doi: 10.1016/s0735-1097(00)00520-9.
We tested the hypothesis that risk of ischemic heart disease (IHD) differs as a function of apolipoprotein E (APOE) genotype in women and men.
Apolipoprotein E genotype influences lipids and lipoproteins and, therefore, possibly the risk of IHD.
We genotyped 9,241 white women and men from the general population and 940 white women and men with IHD.
Test of interaction suggested that APOE genotype may influence risk of IHD differently in women and men (p = 0.07). After age adjustment, the odds ratio (OR) for IHD for epsilon32 versus epsilon33 women was 0.57 (95% confidence interval [CI]: 0.35 to 0.94) while epsilon43 and epsilon44 versus epsilon33 men had ORs of 1.16 (0.96 to 1.41) and 1.58 (1.01 to 2.45). After adjustment for age and other conventional cardiovascular risk factors, the equivalent ORs were for epsilon32 women 0.38 (0.18 to 0.79), for epsilon43 men 1.35 (1.02-1.78) and for epsilon44 men 1.58 (0.80 to 3.08). Equivalent ORs for epsilon43 and epsilon44 versus epsilon33 women and for epsilon32 versus epsilon33 men were all close to 1.0 and nonsignificant. Of the total risk of IHD relative to the epsilon33 genotype, the fraction attributed to epsilon32 in women was -9%, while the fractions attributed to epsilon43 and epsilon44 in men were +8% and +2%.
Relative to epsilon33 individuals, epsilon32 women are protected while epsilon43 and epsilon44 men are particularly susceptible to IHD.
我们检验了这样一个假设，即缺血性心脏病（IHD）的风险因载脂蛋白E（APOE）基因型的不同在女性和男性中存在差异。
载脂蛋白E基因型会影响脂质和脂蛋白，因此可能影响缺血性心脏病的风险。
我们对来自普通人群的9241名白人女性和男性以及940名患有缺血性心脏病的白人女性和男性进行了基因分型。
交互作用检验表明，APOE基因型对缺血性心脏病风险的影响在女性和男性中可能有所不同（p = 0.07）。年龄调整后，ε32与ε33女性患IHD的比值比（OR）为0.57（95%置信区间[CI]：0.35至0.94），而ε43和ε44与ε33男性的OR分别为1.16（0.96至1.41）和1.58（1.01至2.45）。在调整年龄和其他传统心血管危险因素后，ε32女性的等效OR为0.38（0.18至0.79），ε43男性为1.35（1.02 - 1.78），ε44男性为1.58（0.80至3.08）。ε43和ε44与ε33女性以及ε32与ε33男性的等效OR均接近1.0且无统计学意义。相对于ε33基因型的IHD总风险，女性中归因于ε32的比例为 - 9%，而男性中归因于ε43和ε44的比例分别为 + 8%和 + 2%。
相对于ε33个体，ε32女性受到保护，而ε43和ε44男性尤其易患缺血性心脏病。
