Singh B, Alfonso A, Sabin S, Poluri A, Shaha A R, Sundaram K, Lucente F E
Department of Otolaryngology, State University of New York-Health Science Center at Brooklyn and The Long Island College Hospital, NY, USA.
Am J Otolaryngol. 2000 Mar-Apr;21(2):92-7. doi: 10.1016/s0196-0709(00)85004-8.
Younger or older age has a significant impact on the outcome of patients with head and neck cancer. However, the data regarding outcomes based on age are conflicting. The aim of this article is to determine the impact of age on the outcome of laryngeal cancer.
A retrospective study was performed including all patients with squamous cell carcinoma of the larynx for over a 9-year period. The patients were divided into 3 groups based on age. The younger age group included patients 40 years of age and younger, the older group included patients over 80 years of age, and the remaining patients served as the control group. Descriptive statistics were used to summarize study data. Nonparametric quantitative and qualitative analyses were performed using the Mann-Whitney U test and Fisher's exact test, respectively. Survival analysis was performed using the generalized Wilcoxon test. The Cox proportional hazards model was used for multivariate analysis.
Of the 209 patients with laryngeal carcinoma presenting to our institution over a 9-year period, 20 (10%) were < or =40 years and 15 (7%) were > or =80 years of age. No differences in TNM stage at presentation, treatment, or treatment-associated complications were observed based on age. However, younger patients were less likely to report tobacco (50%; P < .001) or alcohol (57%; P = .03) use and more likely to have human immunodeficiency virus infection (50%; P< .001). Older patients showed a trend toward having a worse baseline medical status. Recurrence was significantly more common in older patients (P = .02) and cause-specific survival significantly poorer for both younger and older patients (P = .002).
The presentation and outcome of laryngeal cancer is influenced by the age at presentation. The differences may be related exact reason for the observed survival differences needs to be determined.
年龄较小或较大对头颈癌患者的预后有重大影响。然而，基于年龄的预后数据存在冲突。本文旨在确定年龄对喉癌预后的影响。
进行了一项回顾性研究，纳入了9年期间所有喉鳞状细胞癌患者。根据年龄将患者分为3组。较年轻年龄组包括40岁及以下的患者，较年长组包括80岁以上的患者，其余患者作为对照组。使用描述性统计来总结研究数据。分别使用Mann-Whitney U检验和Fisher精确检验进行非参数定量和定性分析。使用广义Wilcoxon检验进行生存分析。使用Cox比例风险模型进行多变量分析。
在9年期间到我们机构就诊的209例喉癌患者中，20例（10%）年龄≤40岁，15例（7%）年龄≥80岁。在就诊时的TNM分期、治疗或治疗相关并发症方面，未观察到基于年龄的差异。然而，较年轻患者报告吸烟（50%；P<.001）或饮酒（57%；P=.03）的可能性较小，而感染人类免疫缺陷病毒的可能性较大（50%；P<.001）。较年长患者显示出基线医疗状况较差的趋势。复发在较年长患者中明显更常见（P=.02），较年轻和较年长患者的特定病因生存率均明显较差（P=.002）。
喉癌的就诊情况和预后受就诊时年龄的影响。这些差异可能相关，需要确定观察到的生存差异的确切原因。
