Sagripanti A, Carpi A
Department of Internal Medicine, University of Pisa, Italy.
Biomed Pharmacother. 2000 Mar;54(2):107-11. doi: 10.1016/S0753-3322(00)88861-7.
Vascular endothelium plays a key role in the control of haemostasis and thrombosis. The main reactions involved in the regulation of platelet reactivity, blood coagulation and fibrinolysis take place at the luminal surface of endothelial cells. Following exposure to certain pathological stimuli, remarkable functional changes of the endothelial cells occur, including downregulation of antithrombotic mechanisms and upregulation of prothrombotic activities. Based on the recent knowledge of vascular endothelial function, a better understanding of the pathogenesis of atherothrombosis is expected.
血管内皮在止血和血栓形成的控制中起关键作用。调节血小板反应性、血液凝固和纤维蛋白溶解的主要反应发生在内皮细胞的腔表面。在受到某些病理刺激后，内皮细胞会发生显著的功能变化，包括抗血栓形成机制的下调和促血栓形成活性的上调。基于对血管内皮功能的最新认识，有望更好地理解动脉粥样硬化血栓形成的发病机制。
