Wythenshawe Hospital, Manchester University NHS Foundation Trust, Manchester M23 9LT, UK.
Department of Pulmonology, Semmelweis University, 1083 Budapest, Hungary.
Int J Mol Sci. 2023 Sep 15;24(18):14145. doi: 10.3390/ijms241814145.
Cardiovascular diseases (CVD) are among the leading causes of death worldwide. Many lines of evidence suggest that the disturbances in circadian rhythm are responsible for the development of CVDs; however, circadian misalignment is not yet a treatable trait in clinical practice. The circadian rhythm is controlled by the central clock located in the suprachiasmatic nucleus and clock genes (molecular clock) located in all cells. Dyslipidaemia and vascular inflammation are two hallmarks of atherosclerosis and numerous experimental studies conclude that they are under direct influence by both central and molecular clocks. This review will summarise the results of experimental studies on lipid metabolism, vascular inflammation and circadian rhythm, and translate them into the pathophysiology of atherosclerosis and cardiovascular disease. We discuss the effect of time-respected administration of medications in cardiovascular medicine. We review the evidence on the effect of bright light and melatonin on cardiovascular health, lipid metabolism and vascular inflammation. Finally, we suggest an agenda for future research and recommend on clinical practice.
心血管疾病（CVD）是全球主要死亡原因之一。有许多证据表明，昼夜节律紊乱是 CVD 发展的原因；然而，昼夜节律失调在临床实践中尚无法治疗。昼夜节律受位于视交叉上核的中央时钟和位于所有细胞中的时钟基因（分子钟）控制。血脂异常和血管炎症是动脉粥样硬化的两个标志，许多实验研究得出结论，它们直接受到中央时钟和分子钟的影响。本综述将总结关于脂质代谢、血管炎症和昼夜节律的实验研究结果，并将其转化为动脉粥样硬化和心血管疾病的病理生理学。我们讨论了在心血管医学中按时服用药物的效果。我们回顾了关于明亮光线和褪黑素对心血管健康、脂质代谢和血管炎症影响的证据。最后，我们为未来的研究提出了一个议程，并为临床实践提供了建议。
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