Vinogradov E, Perry M B
Institute for Biological Sciences, National Research Council, Ottawa, ON, Canada.
Eur J Biochem. 2000 Apr;267(8):2439-46. doi: 10.1046/j.1432-1327.2000.01262.x.
The structure of lipid A core region of the lipopolysaccharides (LPS) from Proteus mirabilis serotypes O6, O57 and O48 was determined using NMR, MS and chemical analysis of the oligosaccharides, obtained by mild acid hydrolysis, alkaline deacylation, and deamination of LPS: [see text for structure]. Incomplete substitutions are indicated by bold italic type. All sugars are present in pyranose form, alpha-Hep is the residue of L-glycero-alpha-D-manno-Hep, alpha-DD-Hep is the residue of D-glycero-alpha-D-manno-Hep, L-Ara4N is 4-amino-4-deoxy-L-arabinose, Qui4NAlaAla is the residue of 4-N-(L-alanyl-L-alanyl)-4-amino-4,6-dideoxyglucose. All sugars except L-Ara4N have D-configuration. beta-GalA* is partially present in the form of amide with 1,4-diaminobutane (putrescine)-HN(CH2)4NH2 or spermidine-HN(CH2)3NH(CH2)4NH2.
利用核磁共振（NMR）、质谱（MS）以及通过温和酸水解、碱脱酰基和脂多糖（LPS）脱氨获得的寡糖的化学分析，确定了奇异变形杆菌O6、O57和O48血清型脂多糖（LPS）的脂质A核心区域结构：[结构见正文]。不完全取代用粗斜体表示。所有糖类均以吡喃糖形式存在，α-Hep是L-甘油-α-D-甘露庚糖的残基，α-DD-Hep是D-甘油-α-D-甘露庚糖的残基，L-Ara4N是4-氨基-4-脱氧-L-阿拉伯糖，Qui4NAlaAla是4-N-（L-丙氨酰-L-丙氨酰）-4-氨基-4,6-二脱氧葡萄糖的残基。除L-Ara4N外，所有糖类均具有D-构型。β-GalA*部分以与1,4-二氨基丁烷（腐胺）-HN(CH2)4NH2或亚精胺-HN(CH2)3NH(CH2)4NH2形成的酰胺形式存在。
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