Centonze V, Bassi A, Causarano V, Dalfino L, Centonze A, Albano O
Headache Unit, 1st Institute of Internal Medicine, University of Bari, Italy.
Headache. 2000 Jan;40(1):54-6. doi: 10.1046/j.1526-4610.2000.00011.x.
A 42-year-old man came to our headache unit in October 1995 complaining of recurrent attacks of headache, which had begun in February 1991. Chronic cluster headache was diagnosed, and he was given verapamil, 360 mg per day. The attacks ceased in the following months and verapamil was stopped in March 1996. In May 1997, a recurrence of the attacks required the readministration of verapamil, 360 mg per day. The attacks decreased (one to three per week), but after 2 months the patient reported a worsening in his condition due to the appearance of shorter attacks, which were diagnosed as chronic paroxysmal hemicrania. The administration of indomethacin, 225 mg per day, resulted in the disappearance of the short attacks. The concomitant occurrence of attacks of cluster headache and chronic paroxysmal hemicrania suggests the presence of shared factors in the pathophysiology of the two forms of headache. This hypothesis is supported by previous reports in the literature.
一名42岁男性于1995年10月前来我们的头痛科就诊，主诉自1991年2月起反复发作头痛。诊断为慢性丛集性头痛，给予维拉帕米，每日360毫克。接下来的几个月发作停止，维拉帕米于1996年3月停用。1997年5月，发作复发，需要重新服用维拉帕米，每日360毫克。发作次数减少（每周一至三次），但2个月后患者报告病情恶化，因为出现了更短的发作，被诊断为慢性阵发性偏侧头痛。给予吲哚美辛，每日225毫克，短发作消失。丛集性头痛发作与慢性阵发性偏侧头痛同时出现，提示这两种头痛形式在病理生理学上存在共同因素。这一假说得到了文献中先前报告的支持。
