Evers S, Husstedt I W
Department of Neurology, University of Münster, Germany.
Headache. 1996 Jul-Aug;36(7):429-32. doi: 10.1046/j.1526-4610.1996.3607429.x.
Indomethacin is the drug of first choice in chronic paroxysmal hemicrania with clear relief of pain as a diagnostic criterion. In a few cases, indomethacin is not tolerated because of side effects. Therefore, the efficacy of carbamazepine, verapamil, sumatriptan, acetylsalicylic acid, and oxygen as drugs in the prophylactic or acute treatment of chronic paroxysmal hemicrania was studied in a prospective open trial with 10 patients suffering from chronic paroxysmal hemicrania. The trial results, in accordance with a review of the literature, suggest that acetylsalicylic acid (and probably naproxen and diclofenac) and verapamil are the most effective drugs of second choice in chronic paroxysmal hemicrania. The efficacy of sumatriptan in this condition needs still to be clarified, although there is evidence for partial efficacy. Carbamazepine and oxygen did not show any significant influence on chronic paroxysmal hemicrania.
以疼痛明显缓解作为诊断标准时，吲哚美辛是慢性阵发性偏侧头痛的首选药物。在少数情况下，由于副作用，患者无法耐受吲哚美辛。因此，在一项针对10例慢性阵发性偏侧头痛患者的前瞻性开放试验中，研究了卡马西平、维拉帕米、舒马曲坦、乙酰水杨酸和氧气作为慢性阵发性偏侧头痛预防性或急性治疗药物的疗效。试验结果与文献综述一致，表明乙酰水杨酸（可能还有萘普生和双氯芬酸）和维拉帕米是慢性阵发性偏侧头痛最有效的二线药物。舒马曲坦在这种情况下的疗效仍有待明确，尽管有证据表明其有部分疗效。卡马西平和氧气对慢性阵发性偏侧头痛没有显示出任何显著影响。
