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疟疾合并感染儿童的抗血吸虫抗体反应

Anti-schistosome antibody responses in children coinfected with malaria.

作者信息

Mutapi F, Ndhlovu P D, Hagan P, Woolhouse M E

机构信息

Wellcome Trust Centre for the Epidemiology of Infectious Diseases, Department of Zoology, South Parks Road, University of Oxford, Oxford OX1 3PS, UK.

出版信息

Parasite Immunol. 2000 Apr;22(4):207-9. doi: 10.1046/j.1365-3024.2000.00288.x.

DOI:10.1046/j.1365-3024.2000.00288.x
PMID:10760187
Abstract

People residing in schistosome endemic areas are often infected with other parasites. The interaction of the parasites in the host has important implications in the development of acquired immunity to schistosomiasis, and schistosome immuno-epidemiology. An analysis of specific anti-schistosome egg responses in children coinfected with schistosomiasis and malaria shows that malaria positive children produce significantly more anti-schistosome IgE and IgG3 than schistosome infected children who are negative for malaria.

摘要

居住在血吸虫病流行地区的人常常感染其他寄生虫。寄生虫在宿主体内的相互作用对血吸虫病获得性免疫的发展以及血吸虫免疫流行病学具有重要意义。对同时感染血吸虫病和疟疾的儿童的特异性抗血吸虫虫卵反应进行分析表明,疟疾检测呈阳性的儿童产生的抗血吸虫IgE和IgG3明显多于疟疾检测呈阴性的血吸虫感染儿童。

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