Cheng Y, Macera C A, Davis D R, Ainsworth B E, Troped P J, Blair S N
School of Public Health, University of South Carolina, Columbia, SC 29208, USA.
J Clin Epidemiol. 2000 Mar 1;53(3):315-22. doi: 10.1016/s0895-4356(99)00168-7.
This prospective study evaluated regular physical activity and self-reported physician-diagnosed osteoarthritis of the knee and/or hip joints among 16,961 people, ages 20-87, examined at the Cooper Clinic between 1970 and 1995. Among those aged 50 years and older, osteoarthritis incidence was higher among women (7.0 per 1000 person-years) than among men (4.9 per 1000 person-years, P = 0.001), while among those under 50 years of age, osteoarthritis incidence was similar between men (2.6) and women (2.7). High levels of physical activity (running 20 or more miles per week) were associated with osteoarthritis among men under age 50 after controlling for body mass index, smoking, and use of alcohol or caffeine (hazard ratio = 2.4, 95% CI: 1.5, 3.9), while no relationship was suggested among women or older men. These findings support the conclusion that high levels of physical activity may be a risk factor for symptomatic osteoarthritis among men under age 50.
这项前瞻性研究评估了1970年至1995年期间在库珀诊所接受检查的16961名年龄在20至87岁之间的人群的规律体育活动以及自我报告的经医生诊断的膝关节和/或髋关节骨关节炎情况。在50岁及以上人群中，女性骨关节炎发病率（每1000人年7.0例）高于男性（每1000人年4.9例，P = 0.001），而在50岁以下人群中，男性（2.6例）和女性（2.7例）的骨关节炎发病率相似。在控制体重指数、吸烟以及酒精或咖啡因使用情况后，高水平体育活动（每周跑步20英里或更多）与50岁以下男性的骨关节炎相关（风险比 = 2.4，95%置信区间：1.5，3.9），而在女性或老年男性中未发现这种关联。这些发现支持了以下结论：高水平体育活动可能是50岁以下男性出现症状性骨关节炎的一个风险因素。
