Gessler D D, Xu S
Department of Botany and Plant Sciences, University of California, Riverside 92521, USA.
Genetica. 1999;105(3):281-91. doi: 10.1023/a:1003981620837.
We present a multipoint algorithm for mapping quantitative trait loci (QTLs) using dominant markers. The algorithm is designed for outbred populations and is particularly suited for large families. The algorithm works with either codominant or dominant markers, either of which may be interspersed within the same linkage map. Concurrently, the algorithm also partitions dominance variance at the QTL. Computer simulations show that with large families, QTL mapping with dominant markers can be almost as powerful as with bi-allelic, codominant markers. Yet despite this, other situations show a large standard deviation in the estimate of the QTL position, thus making QTL mapping with dominant markers in outbred populations a useful detection tool, albeit limited in its resolution.
我们提出了一种使用显性标记定位数量性状基因座（QTL）的多点算法。该算法专为远交群体设计，特别适用于大家庭。该算法适用于共显性或显性标记，这两种标记可以穿插在同一张连锁图中。同时，该算法还能对QTL处的显性方差进行划分。计算机模拟表明，对于大家庭而言，使用显性标记进行QTL定位几乎与使用双等位基因共显性标记一样有效。然而，尽管如此，在其他情况下，QTL位置估计的标准差很大，因此，在远交群体中使用显性标记进行QTL定位是一种有用的检测工具，尽管其分辨率有限。
