[乙醇抑制酒精中毒患者血小板B型单胺氧化酶活性]
[Ethanol inhibits platelet monoamine oxidase type B activity in patients with alcoholism].
作者信息
Krupitskiĭ E M, Karandashova G F, Vostrikov V V, Lavrova N M, Grinenko N I, Slavina T Iu, Grinenko A Ia
机构信息
Regional Scientific Center for Research in Addictions and Psychopharmacology, Pavlov St. Petersburg State Medical University.
出版信息
Vopr Med Khim. 1999 Nov-Dec;45(6):489-93.
The influence of 400 mM ethanol on the activity of monoamine oxidase type B (MAO-B) of blood platelets has been studied in vitro in 30 alcoholic patients and 30 healthy volunteers. Benzylamine was used as a substrate for MAO-B. MAO-B inhibition by ethanol was higher in alcoholics compared to healthy volunteers. The higher vulnerability of MAO-B of alcoholics inhibiting action to of ethanol may be one of the mechanisms underlying some symptoms of alcoholism.
在30名酒精性肝病患者和30名健康志愿者中，对400 mM乙醇对血小板中B型单胺氧化酶（MAO-B）活性的影响进行了体外研究。苄胺用作MAO-B的底物。与健康志愿者相比，酒精性肝病患者中乙醇对MAO-B的抑制作用更高。酒精性肝病患者的MAO-B对乙醇抑制作用的更高易感性可能是酒精中毒某些症状的潜在机制之一。
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