Demisch L, Gebhart P, Kaczmarczyk P, von der Mühlen H, Bochnik H J
Biol Psychiatry. 1981 Jan;16(1):21-33.
The influence of plasma and low and high molecular weight plasma fraction on MAO activity in platelets from controls were studied. Plasmas were obtained from patients with decreased platelet MAO activity and suffering from chronic schizophrenia of different syndrome subtypes, unipolar depressions, and alcoholism. Up to 50% inhibition and activation of MAO activity alterations were not different between the plasmas from schizophrenic, depressive, and alcoholic patients. Plasmas from schizophrenic patients without medication or on neuroleptics showed similar inhibition and/or activation of MAO activity in platelets from controls. The results indicate, in accordance with recent findings, that a number of low and high molecular weight substances can trigger platelet MAO activity changes. These plasma factors do not appear to be characteristic of schizophrenic patients with low platelet MAO activity.
研究了血浆以及低分子量和高分子量血浆组分对对照组血小板中MAO活性的影响。血浆取自血小板MAO活性降低且患有不同综合征亚型的慢性精神分裂症、单相抑郁症和酒精中毒患者。在精神分裂症、抑郁症和酒精中毒患者的血浆之间，高达50%的MAO活性抑制和激活的变化并无差异。未用药或服用抗精神病药物的精神分裂症患者的血浆，对对照组血小板中MAO活性的抑制和/或激活情况相似。结果表明，与最近的研究结果一致，一些低分子量和高分子量物质可引发血小板MAO活性变化。这些血浆因子似乎并非血小板MAO活性低的精神分裂症患者所特有。
