[阿司匹林与心血管风险的预防]
[Aspirin and prevention of cardiovascular risk].
作者信息
Karila-Cohen D, Gabriel Steg P
机构信息
Service de cardiologie, hôpital Bichat, Paris, France.
出版信息
Rev Med Interne. 2000 Mar;21 Suppl 1:35s-40s. doi: 10.1016/s0248-8663(00)88723-8.
PURPOSE
Aspirin, a potent platelet inhibitor, is widely used in patients with cardiovascular diseases. Platelet aggregation is the cornerstone of acute atherothrombotic complications.
ACTUALITIES
Aspirin showed significant benefits when administered in patients with acute myocardial infarction or unstable angina, and also when used for secondary prevention in patients with known coronary artery disease. Aspirin has been evaluated in primary prevention, with interesting results in high-risk patients. Finally, aspirin can be used in some patients with supraventricular arrhythmias or with mechanical valves.
PERSPECTIVES
Further investigation concerning the exact role of aspirin in primary prevention is currently being done. The association of aspirin with new antiplatelet agents in patients with acute coronary syndromes has shown interesting results.
目的
阿司匹林是一种强效血小板抑制剂，广泛应用于心血管疾病患者。血小板聚集是急性动脉粥样硬化血栓形成并发症的基石。
现状
阿司匹林在急性心肌梗死或不稳定型心绞痛患者中使用时显示出显著益处，在已知冠状动脉疾病患者的二级预防中使用时也是如此。阿司匹林已在一级预防中进行了评估，在高危患者中取得了有趣的结果。最后，阿司匹林可用于一些室上性心律失常患者或机械瓣膜患者。
展望
目前正在对阿司匹林在一级预防中的确切作用进行进一步研究。阿司匹林与急性冠状动脉综合征患者的新型抗血小板药物联合使用已显示出有趣的结果。
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