Roberts K J
University of California, Los Angeles, USA.
AIDS Patient Care STDS. 2000 Mar;14(3):155-68. doi: 10.1089/108729100317948.
HIV-positive patients must strictly adhere to antiretroviral regimens for the medications to work properly. Little, however, is known about the obstacles that patients face in adhering to the regimens or what, if anything, helps patients to adhere. The goals of the project were to describe, from HIV-positive patients' own perspectives, the barriers they face in adhering to antiretroviral regimens and the strategies they use to maximize their adherence. Five main barriers (forgetfulness, social/physical environment, complexity of the regimens, medication side effects, and inadequate patient knowledge) to adherence and six main facilitators (mechanical devices, "making a commitment," "routinizing," health beliefs, social support, and professional support) emerged from the data. Patients may overcome some of these barriers by receiving better health education about the need for adherence, professional and lay support for their efforts, and mechanical devices such as alarm clocks and medi-sets. Other barriers, however, such as the complexity of the medications, highlight the need for simplified antiretroviral regimens.
HIV 阳性患者必须严格遵守抗逆转录病毒治疗方案，药物才能正常发挥作用。然而，对于患者在坚持治疗方案时所面临的障碍，或者什么因素（如果有的话）有助于患者坚持治疗，我们知之甚少。该项目的目标是从 HIV 阳性患者自身的角度描述他们在坚持抗逆转录病毒治疗方案时所面临的障碍以及他们为提高依从性所采用的策略。数据显示，坚持治疗存在五个主要障碍（健忘、社会/身体环境、治疗方案复杂、药物副作用和患者知识不足）和六个主要促进因素（机械设备、“做出承诺”、“常规化”、健康信念、社会支持和专业支持）。患者可以通过接受关于坚持治疗必要性的更好的健康教育、获得对其努力的专业和非专业支持以及使用闹钟和药盒等机械设备来克服其中一些障碍。然而，其他障碍，如药物治疗方案的复杂性，凸显了简化抗逆转录病毒治疗方案的必要性。
