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[放牧奶牛瘤胃内容物、肝脏和肾脏中的连苯三酚浓度]

[Pyrogallol concentrations in rumen content, liver and kidney of cows at pasture].

作者信息

Meiser H, Hagedorn H W, Schulz R

机构信息

Institut für Pharmakologie, Toxikologie und Pharmazie, Tierärztliche Fakultät der Ludwig-Maximilians-Universität München.

出版信息

Berl Munch Tierarztl Wochenschr. 2000 Mar;113(3):108-11.

Abstract

Pyrogallol (1, 2, 3-trihydroxybenzene), the decomposition product of hydrolysable tannins in oak bark, leaves and acorns, is suspected to be poisonous to animals. The aim of our investigations was to correlate clinical signs and pathological findings with pyrogallol concentrations in organs of poisoned and healthy animals. In a field study, pyrogallol concentrations were determined in liver, kidney, and rumen from seven cattle. In a herd of twelve cows, five animals suffered from hemorrhagic diarrhea, anorexia, weakness, rumen stasis, dyspnoea, and colic symptoms. Death was observed in five cows within five weeks after repeated intake of green acorns and oak leaves. Toxicological analyses of rumen content, liver, and kidney specimens of one cattle confirmed the suspicion of pyrogallol contamination. In this animal, values ranged from 6 to 13 ng pyrogallol per gram specimen. In control cattle, concentrations were clearly lower than in perished cattle. Under antioxidative work-up conditions, detection limit was 0.6 ng/g in rumen content and 1.0 ng/g in liver and kidney, respectively.

摘要

焦性没食子酸(1,2,3 - 三羟基苯)是橡树树皮、树叶和橡子中可水解单宁的分解产物,被怀疑对动物有毒。我们研究的目的是将中毒和健康动物器官中的临床症状、病理发现与焦性没食子酸浓度联系起来。在一项实地研究中,测定了七头牛肝脏、肾脏和瘤胃中的焦性没食子酸浓度。在一群12头奶牛中,5头出现出血性腹泻、厌食、虚弱、瘤胃积食、呼吸困难和绞痛症状。在反复摄入青橡子和橡树叶后的五周内,观察到5头奶牛死亡。对一头牛的瘤胃内容物、肝脏和肾脏标本进行的毒理学分析证实了对焦性没食子酸污染的怀疑。在这头牛中,每克标本中焦性没食子酸的值在6至13纳克之间。在对照牛中,浓度明显低于死亡牛。在抗氧化处理条件下,瘤胃内容物的检测限为0.6纳克/克,肝脏和肾脏的检测限分别为1.0纳克/克。

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