Panter K E, Molyneux R J, Smart R A, Mitchell L, Hansen S
USDA Agricultural Research Service (ARS) Poisonous Plant Research Lab, Logan, UT 84321.
J Am Vet Med Assoc. 1993 May 1;202(9):1476-7.
Thirty-five privately owned 1- to 2-year-old mixed-breed steers and heifers, weighing 340 to 454 kg, died from accidental ingestion of English yew (Taxus baccata). Estimated dosages ranged from 0.36 to 0.70 g of fresh plant/kg of body weight. Clinical signs of poisoning and death began 2 to 3 hours after first exposure, and cattle continued to have clinical signs, which ended in death 6 to 8 hours later. Most cattle had died by 4 hours after first ingestion. Necropsy of 4 cattle revealed substantial amounts of English yew leaves and small stems in the rumen contents. Grossly, there were areas of hyperemia in the abomasum and small intestine. Histologically, lesions were limited to the lungs and included moderate congestion and interlobular edema. Chemical analysis by thin-layer chromatography of suspected yew plant material from the rumen contents of the 4 necropsied cattle was compared to authentic taxol, and confirmed the presence of taxol in rumen samples.
35头1至2岁的私有杂交品种公牛和小母牛，体重340至454千克，因意外摄入欧洲红豆杉（Taxus baccata）而死亡。估计摄入量为每千克体重0.36至0.70克新鲜植物。中毒临床症状和死亡在首次接触后2至3小时开始出现，牛持续出现临床症状，6至8小时后死亡。大多数牛在首次摄入后4小时内死亡。对4头牛进行尸检，发现瘤胃内容物中有大量欧洲红豆杉树叶和小茎。大体检查发现，皱胃和小肠有充血区域。组织学检查显示，病变仅限于肺部，包括中度充血和小叶间水肿。通过薄层色谱法对4头尸检牛瘤胃内容物中疑似红豆杉植物材料进行化学分析，并与紫杉醇真品进行比较，证实瘤胃样本中存在紫杉醇。
