多中心性网状组织细胞增生症：病例报告及免疫组化分析与文献复习

Multicentric reticulohistiocytosis: case report with immunohistochemical analysis and literature review.

作者信息

Gorman J D, Danning C, Schumacher H R, Klippel J H, Davis J C

机构信息

University of California, San Francisco 94143, USA.

出版信息

Arthritis Rheum. 2000 Apr;43(4):930-8. doi: 10.1002/1529-0131(200004)43:4<930::AID-ANR27>3.0.CO;2-A.

DOI:10.1002/1529-0131(200004)43:4<930::AID-ANR27>3.0.CO;2-A

PMID:10765941

Abstract

This report describes the case of a patient with multicentric reticulohistiocytosis. Immunohistochemical analysis revealed prominent markers of monocyte/macrophage origin, as well as the presence of tumor necrosis factor alpha, interleukin-1beta (IL-1beta), and IL-12; the occurrence of the latter in this disease has not previously been reported. Clinical, laboratory, radiographic, and histologic findings in multicentric reticulohistiocytosis are reviewed. In addition, all published cases of multicentric reticulohistiocytosis which included reports of cytokine and immunohistochemical analysis are reviewed, and evidence for a monocyte/macrophage origin and role in disease pathogenesis is provided.

摘要

本报告描述了一例多中心网状组织细胞增多症患者的病例。免疫组织化学分析显示出单核细胞/巨噬细胞来源的显著标志物，以及肿瘤坏死因子α、白细胞介素-1β（IL-1β）和IL-12的存在；后者在该疾病中的出现此前尚未见报道。本文对多中心网状组织细胞增多症的临床、实验室、影像学和组织学检查结果进行了综述。此外，还对所有已发表的多中心网状组织细胞增多症病例进行了综述，这些病例包括细胞因子和免疫组织化学分析报告，并提供了关于单核细胞/巨噬细胞起源及其在疾病发病机制中的作用的证据。