Nakajima Y, Sato K, Morita H, Torikai S, Hidano A, Nishioka K, Kashiwazaki S
Institute of Rheumatology, Tokyo Women's Medical College, Japan.
J Rheumatol. 1992 Oct;19(10):1643-6.
A case of multicentric reticulohistiocytosis complicated by severe progressive erosive arthritis in a 40-year-old man is described. The diagnosis was confirmed by biopsies of the cutaneous nodule and the synovial tissue of the right knee joint. Destructive changes in the multiple joints rapidly progressed and resulted in severe progressive erosive arthritis. Immunohistochemical staining revealed that the histiocytes reacted positively to interleukin 1 beta and platelet derived growth factor B, leading to the speculation that these cytokines may play a role in the synovial proliferation seen in patients with multicentric reticulohistiocytosis.
本文描述了一名40岁男性多中心网状组织细胞增生症并发严重进行性侵蚀性关节炎的病例。通过对皮肤结节和右膝关节滑膜组织进行活检确诊。多个关节的破坏性改变迅速进展，导致严重的进行性侵蚀性关节炎。免疫组织化学染色显示，组织细胞对白介素1β和血小板衍生生长因子B呈阳性反应，这引发了一种推测，即这些细胞因子可能在多中心网状组织细胞增生症患者的滑膜增生中发挥作用。
