Vamnes J S, Eide R, Isrenn R, Höl P J, Gjerdet N R
University of Bergen, Department of Odontology-Dental Biomaterials, Norway.
J Dent Res. 2000 Mar;79(3):868-74. doi: 10.1177/00220345000790031401.
The chelating agent 2,3 dimercaptopropane-1-sulfonate (DMPS) has been used in a mercury mobilization test for diagnoses in illnesses allegedly associated with the presence of amalgam restorations. DMPS is an accepted antidote to heavy metal poisoning. The aim of the present study was to evaluate the diagnostic value of DMPS in patients with symptoms self-related to their amalgam fillings. The subjects consisted of four groups: 19 healthy controls without amalgam experience; 21 healthy controls with amalgam fillings; 20 patients who claimed symptoms of "mercury poisoning" from dental amalgam; and 20 patients who had amalgam fillings removed because of such symptoms. DMPS (2 mg/kg body weight) was injected intravenously, and urine was collected prior to the injection, 30 and 120 min after the injection, and throughout the next 22 hrs. The samples were analyzed for total mercury by cold vapor atomic absorption spectrophotometry. The total median amounts of mercury excreted over 24 hrs for those with complaints allegedly associated with amalgam and for the healthy controls with amalgam fillings were similar. Persons with amalgam fillings excreted about three times more mercury than those without. The controls, who had never had amalgam fillings, and the subjects who had had their fillings removed excreted median amounts of 8.5 microg and 7.2 microg mercury, respectively. The present DMPS challenge test did not differentiate between patients with or those without complaints self-related to their amalgam fillings but did confirm the higher mercury values in patients with dental amalgam.
螯合剂2,3 - 二巯基丙烷 - 1 - 磺酸盐（DMPS）已用于汞动员试验，以诊断据称与汞合金修复体存在相关的疾病。DMPS是公认的重金属中毒解毒剂。本研究的目的是评估DMPS对自述有汞合金填充物相关症状患者的诊断价值。研究对象分为四组：19名无汞合金接触史的健康对照者；21名有汞合金填充物的健康对照者；20名声称因牙科汞合金出现“汞中毒”症状的患者；以及20名因此类症状而拔除汞合金填充物的患者。静脉注射DMPS（2mg/kg体重），在注射前、注射后30分钟和120分钟以及接下来的22小时内收集尿液。通过冷蒸气原子吸收分光光度法分析样品中的总汞。据称有汞合金相关症状的患者和有汞合金填充物的健康对照者在24小时内排出的汞总量中位数相似。有汞合金填充物的人排出的汞比没有的人多约三倍。从未有过汞合金填充物的对照者和已拔除填充物的受试者排出的汞中位数分别为8.5微克和7.2微克。目前的DMPS激发试验未能区分自述有汞合金填充物相关症状的患者和无此类症状的患者，但确实证实了有牙科汞合金的患者汞值较高。
