胸苷磷酸化酶/血小板衍生内皮细胞生长因子在癌症化疗中的作用：化学视角
The rôle of thymidine phosphorylase/PD-ECGF in cancer chemotherapy: a chemical perspective.
作者信息
Cole C, Foster A J, Freeman S, Jaffar M, Murray P E, Strafford I J
机构信息
School of Pharmacy and Pharmaceutical Sciences, University of Manchester, UK.
出版信息
Anticancer Drug Des. 1999 Oct;14(5):383-92.
PMID:10766293
Abstract
The angiogenic growth factor thymidine phosphorylase/PD-ECGF has been identified as a potential target in the development of anti-cancer drugs. This review firstly discusses the biological rôle of TP/PD-ECGF and its importance in the activation of 5-fluorouracil and its prodrugs. The chemistry and chemotherapeutic potential of TP/PD-ECGF inhibitors are also discussed.
摘要
血管生成生长因子胸苷磷酸化酶/血小板衍生内皮细胞生长因子已被确定为抗癌药物研发中的一个潜在靶点。本综述首先讨论了胸苷磷酸化酶/血小板衍生内皮细胞生长因子的生物学作用及其在5-氟尿嘧啶及其前体药物激活中的重要性。还讨论了胸苷磷酸化酶/血小板衍生内皮细胞生长因子抑制剂的化学性质和化疗潜力。
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