Lee J W
Department of Neurology, College of Medicine, The Catholic University of Korea, Seoul.
Arch Neurol. 2000 Apr;57(4):597-9. doi: 10.1001/archneur.57.4.597.
Manganese plays an important role as a cofactor in many enzymatic reactions in humans but in excess amounts can cause irreversible nervous system damage. Although manganism is a rare condition, it can be the cause of complex nervous system symptoms, especially in the setting of environmental exposure. Specifically, manganese is a well-known cause of dystonic parkinsonism. This article highlights several historical descriptions of the clinical manifestations, pathological changes, and attempted therapeutic intervention in manganese intoxication.
锰作为人体许多酶促反应中的辅助因子发挥着重要作用，但过量的锰会导致不可逆的神经系统损伤。尽管锰中毒是一种罕见的病症，但它可能是复杂神经系统症状的病因，尤其是在环境暴露的情况下。具体而言，锰是肌张力障碍性帕金森综合征的一个众所周知的病因。本文重点介绍了锰中毒的临床表现、病理变化以及尝试性治疗干预的一些历史描述。
