Bock N, Meden H, Regenbrecht M, Jünemann B, Wangerin J, Marx D
Department of Pathology, University of Göttingen, Germany.
Anticancer Res. 2000 Jan-Feb;20(1A):119-24.
Dysregulations in the mechanism of DNA-repair are contributed to tumorgenesis and tumorprogression in human cancer. The mismatch repair gene hMSH2 encodes a protein, which recognizes and binds to mismatch-sequences of the DNA.
Using immunohistochemical techniques hMSH2 expression was analyzed in invasive cancer (n = 85) and in situ carcinoma (n = 34) of the breast.
The percentage of hMSH2 positive cases was significantly (p = 0.0001) decreased in invasive cancer as compared to in situ carcinomas. There was an association of hMSH2 expression with parameters of unfavorable prognosis, such as lymph node involvement (p = 0.03), higher degree of malignancy (p = 0.05) and higher proliferative activity (p = 0.05).
During development from in situ to invasive cancer of the breast, hMSH2 expression seems to be downregulated. However, in invasive cancer, hMSH2 expression seems to be associated with tumor progression. This could be explained by the fact that enhanced proliferation of tumor cells results in increased mistakes within DNA replication procedures.
DNA修复机制失调在人类癌症的肿瘤发生和肿瘤进展中起作用。错配修复基因hMSH2编码一种蛋白质，该蛋白质识别并结合DNA的错配序列。
采用免疫组织化学技术分析85例乳腺浸润癌和34例乳腺原位癌中hMSH2的表达情况。
与原位癌相比，浸润癌中hMSH2阳性病例的百分比显著降低（p = 0.0001）。hMSH2表达与不良预后参数相关，如淋巴结受累（p = 0.03）、更高的恶性程度（p = 0.05）和更高的增殖活性（p = 0.05）。
在乳腺原位癌发展为浸润癌的过程中，hMSH2表达似乎下调。然而，在浸润癌中，hMSH2表达似乎与肿瘤进展相关。这可以用肿瘤细胞增殖增强导致DNA复制过程中错误增加这一事实来解释。
