Clementi F, Fornasari D, Gotti C
Department of Medical Pharmacology, CNR Cellular and Molecular Pharmacology Center, University of Milan, Via Vanvitelli 32, 20129, Milan, Italy.
Eur J Pharmacol. 2000 Mar 30;393(1-3):3-10. doi: 10.1016/s0014-2999(00)00066-2.
Acetylcholine receptors are cationic channels whose opening is controlled by acetylcholine. They are key molecules in the cholinergic nicotinic transmission in a number of areas of the central and peripheral nervous system. Because of the structural complexity, given by the numerous subunits that forms these receptors, they have different pharmacological and biophysical properties. Here we give a brief account of the known and consolidated data regarding neuronal nicotinic receptors, as as an introduction to the articles reported in this issue, in order to allow readers who are not familiar with the field to place the detailed information in the right context.
乙酰胆碱受体是阳离子通道，其开放受乙酰胆碱控制。它们是中枢和外周神经系统多个区域胆碱能烟碱传递中的关键分子。由于构成这些受体的众多亚基赋予其结构复杂性，它们具有不同的药理和生物物理特性。在此，我们简要介绍有关神经元烟碱受体的已知和确凿数据，作为本期所报道文章的引言，以便不熟悉该领域的读者能在正确的背景下理解详细信息。
