Luetje C W, Patrick J, Séguéla P
Division of Neuroscience, Baylor College of Medicine, Houston, Texas 77030.
FASEB J. 1990 Jul;4(10):2753-60. doi: 10.1096/fasebj.4.10.2197155.
Nicotine is a drug of abuse that presumably exerts its psychoactive effect through its interactions with nicotine binding sites in the central nervous system. Among its potential sites of action are the neuronal nicotinic acetylcholine receptors and the neuronal alpha-bungarotoxin binding sites. In this review we focus on the neuronal nicotinic acetylcholine receptors, their diversity, distribution, and functions as nicotine receptors or as mediators of synaptic transmission in the mammalian brain. We find that the complexity characteristic of the gene family encoding the subunits of these receptors is reflected both in the pattern of expression of the genes and in the pharmacological diversity of the expressed receptors.
尼古丁是一种滥用药物，据推测它通过与中枢神经系统中的尼古丁结合位点相互作用来发挥其精神活性作用。其潜在的作用位点包括神经元烟碱型乙酰胆碱受体和神经元α-银环蛇毒素结合位点。在本综述中，我们聚焦于神经元烟碱型乙酰胆碱受体，包括它们的多样性、分布以及在哺乳动物大脑中作为尼古丁受体或突触传递介质的功能。我们发现，编码这些受体亚基的基因家族的复杂性特征既反映在基因的表达模式中，也反映在表达受体的药理学多样性中。
