Ikeda K, Matsushita M, Ando S, Sekigawa I, Iida N, Hashimoto H
Department of Medicine, Juntendo University Izu-Nagaoka Hospital.
Nihon Rinsho Meneki Gakkai Kaishi. 2000 Feb;23(1):37-42. doi: 10.2177/jsci.23.37.
Recent reports have indicated that antiphospholipid antibodies (aPL) are related to other clinical manifestations such as cardiac valve lesions and hemolytic anemia besides the major clinical features of antiphospholipid syndrome (APS), including thrombocytopenia, and recurrent fetal demise. We recently encountered a case of multiple hormonal deficiencies in the pituitary gland and hypothyroidism associated with an APS. Hypopituitarism of the patient had occurred after her delivery and a magnetic resonance imaging (MRI) examination disclosed "empty sella" of the hypophysis, so she was thought to have Sheehan's syndrome. There has been a few reports describing the relationship between aPL and endocrine disorders. aPL-related onset of these diseases may be more frequent than is generally appreciated.
最近的报告表明，除了抗磷脂综合征（APS）的主要临床特征（包括血小板减少和反复胎儿死亡）外，抗磷脂抗体（aPL）还与其他临床表现有关，如心脏瓣膜病变和溶血性贫血。我们最近遇到了一例与APS相关的垂体多种激素缺乏和甲状腺功能减退的病例。患者的垂体功能减退发生在分娩后，磁共振成像（MRI）检查显示垂体“空蝶鞍”，因此她被认为患有席汉综合征。关于aPL与内分泌紊乱之间关系的报道较少。这些疾病由aPL相关引发的频率可能比普遍认为的更高。
