Essaïs O, Ouertani H, Bouzid C, Zidi B
Service d'Endocrinologie-Diabétologie, Hôpital Militaire Tunis, Tunisie.
Ann Endocrinol (Paris). 2003 Oct;64(4):305-8.
Endocrine disorders seen in antiphospholipid syndrome are rare. To date, these disorders have generally involved Addison's disease. Recently reports have appeared of a few cases of primary or secondary hypopituitarism associated with primary antiphospholipid syndrome. We report the case of a young female patient who presented neuroendocrine symptoms during the postpartum period associated with an antiphospholipid syndrome. Hormone assessment showed complete anterior hypopituitarism and antiphospholipid antibodies were positive. We discuss the clinical, biological and radiological features observed in our patient and compare results with cases reported in the literature. This case illustrates the importance of screening for antiphospholipid syndrome in the etiological work-up of hypopituitarism associated with a history of recurrent thrombosis.
抗磷脂综合征中出现的内分泌紊乱较为罕见。迄今为止，这些紊乱通常涉及艾迪生病。最近有报道称几例原发性或继发性垂体功能减退与原发性抗磷脂综合征相关。我们报告了一例年轻女性患者，她在产后出现了与抗磷脂综合征相关的神经内分泌症状。激素评估显示完全性垂体前叶功能减退，抗磷脂抗体呈阳性。我们讨论了在我们患者中观察到的临床、生物学和放射学特征，并将结果与文献报道的病例进行了比较。该病例说明了在对伴有复发性血栓形成病史的垂体功能减退进行病因检查时筛查抗磷脂综合征的重要性。
