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本文引用的文献

1
Yeast autonomously replicating sequence binding factor is involved in nucleotide excision repair.酵母自主复制序列结合因子参与核苷酸切除修复。
Genes Dev. 1999 Dec 1;13(23):3052-8. doi: 10.1101/gad.13.23.3052.
2
Light and dark in chromatin repair: repair of UV-induced DNA lesions by photolyase and nucleotide excision repair.染色质修复中的光与暗：光裂合酶和核苷酸切除修复对紫外线诱导的DNA损伤的修复
EMBO J. 1999 Dec 1;18(23):6585-98. doi: 10.1093/emboj/18.23.6585.
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Mapping cyclobutane-pyrimidine dimers in DNA and using DNA-repair by photolyase for chromatin analysis in yeast.绘制DNA中的环丁烷嘧啶二聚体，并利用光解酶进行DNA修复以分析酵母中的染色质。
Methods Enzymol. 1999;304:447-61. doi: 10.1016/s0076-6879(99)04027-6.
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DNA damage recognition during nucleotide excision repair in mammalian cells.哺乳动物细胞核苷酸切除修复过程中的DNA损伤识别
Biochimie. 1999 Jan-Feb;81(1-2):39-44. doi: 10.1016/s0300-9084(99)80036-4.
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Molecular mechanism of nucleotide excision repair.核苷酸切除修复的分子机制。
Genes Dev. 1999 Apr 1;13(7):768-85. doi: 10.1101/gad.13.7.768.
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Cell cycle dependent topological changes of chromosomal replication origins in Saccharomyces cerevisiae.酿酒酵母中染色体复制起点的细胞周期依赖性拓扑变化。
Genes Cells. 1998 Nov;3(11):737-49. doi: 10.1046/j.1365-2443.1998.00226.x.
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Modulation of DNA damage and DNA repair in chromatin.染色质中DNA损伤与DNA修复的调控
Prog Nucleic Acid Res Mol Biol. 1999;62:227-55. doi: 10.1016/s0079-6603(08)60509-7.
8
TATA-binding protein promotes the selective formation of UV-induced (6-4)-photoproducts and modulates DNA repair in the TATA box.TATA 结合蛋白促进紫外线诱导的（6-4）光产物的选择性形成，并调节 TATA 框中的 DNA 修复。
EMBO J. 1999 Jan 15;18(2):433-43. doi: 10.1093/emboj/18.2.433.
9
RNA polymerase II transcription suppresses nucleosomal modulation of UV-induced (6-4) photoproduct and cyclobutane pyrimidine dimer repair in yeast.RNA聚合酶II转录抑制酵母中紫外线诱导的（6-4）光产物和环丁烷嘧啶二聚体修复的核小体调节。
Mol Cell Biol. 1999 Jan;19(1):934-40. doi: 10.1128/MCB.19.1.934.
10
Assembly, subunit composition, and footprint of human DNA repair excision nuclease.人类DNA修复切除核酸酶的组装、亚基组成及足迹
Proc Natl Acad Sci U S A. 1998 Jun 9;95(12):6669-74. doi: 10.1073/pnas.95.12.6669.

酵母复制起点处的DNA修复：光解酶和核苷酸切除修复的作用

DNA repair in a yeast origin of replication: contributions of photolyase and nucleotide excision repair.

作者信息

Suter B, Wellinger R E, Thoma F

机构信息

Institut für Zellbiologie, ETH-Zürich, Hönggerberg, CH-8093 Zürich, Switzerland.

出版信息

Nucleic Acids Res. 2000 May 15;28(10):2060-8. doi: 10.1093/nar/28.10.2060.

DOI:10.1093/nar/28.10.2060
PMID:10773073
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC105381/
Abstract

DNA damage formation and repair are tightly linked to protein-DNA interactions in chromatin. We have used minichromosomes in yeast as chromatin substrates in vivo to investigate how nucleotide excision repair (NER) and repair by DNA-photolyase (photoreactivation) remove pyrimidine dimers from an origin of replication ( ARS1 ). The ARS1 region is nuclease sensitive and flanked by nucleosomes on both sides. Photoreactivation was generally faster than NER at all sites. Site-specific heterogeneity of repair was observed for both pathways. This heterogeneity was different for NER and photoreactivation and it was altered in a minichromosome where ARS1 was transcribed. The results indicate distinct inter-actions of the repair systems with protein complexes bound in the ARS region (ORC, Abf1) and a predominant role of photolyase in CPD repair of an origin of replication.

摘要

DNA损伤的形成与修复与染色质中蛋白质-DNA的相互作用紧密相关。我们利用酵母中的微型染色体作为体内染色质底物，来研究核苷酸切除修复（NER）和DNA光解酶修复（光复活）如何从复制起点（ARS1）去除嘧啶二聚体。ARS1区域对核酸酶敏感，两侧均有核小体。在所有位点，光复活通常比NER更快。两种修复途径均观察到位点特异性的修复异质性。NER和光复活的这种异质性不同，并且在转录ARS1的微型染色体中发生了改变。结果表明修复系统与结合在ARS区域的蛋白质复合物（ORC、Abf1）存在不同的相互作用，并且光解酶在复制起点的CPD修复中起主要作用。